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At a follow-up visit 1 month after treatment, her 9-year-old son said “I have got my mummy back.” Twelve months after her treatment, she continues to be a bright, happy person and is participating in a “return to work” program. Table 1 presents the BDI and the HAMD-17 score for patient A before her first ketamine treatment and at subsequent office visits.Patient B is a 33-year-old, 101 kg man whose depression dated from his mid-teens and for the last 4 years had been constant.
When treating patients suffering from complex regional pain syndrome (CRPS) with a low-dose (subanesthetic) ketamine infusion [1–3], it was observed that some patients made a significant recovery from associated depression.
After 48 hours, the patient said he felt better in his mood, and nursing staff noted that he appeared brighter and was more spontaneous in his speech and expressions.
After 72 hours, he was talking positively about his future plans, interacting with staff, and initiating conversation.
He required a third course of treatment after another 6 months.
Twelve months after his first infusion cycle, he remains bright and happy.