(I wrote in more detail about the theory behind this approach earlier this year).
Two types of mi RNA increased in number during storage and two declined, said graduate student Wen-Hsuan Yang, who performed the biochemistry experiments.
One of the forms that declined, called mi R-70, had the most dramatic and consistent changes.
The best detection method the World Anti-Doping Agency (WADA) has used to date is the "Athlete Passport," which compares a pre-competition blood sample to one taken at competition to see if there are 'significant' changes in biochemistry. consider 42 days the outer limit of how long a unit of red blood cells should be stored because of biochemical changes that could harm recipients.
"The difficulty has been that the tests they have couldn't tell the difference between a young blood cell and an old one," said Jen-Tsan "Ashley" Chi, M. D., who led this WADA-funded research in his lab at Duke's Center for Genomic and Computational Biology. The amount of energy-providing ATP drops and oxygen-binding hemoglobin declines as well.